Video 1

Movie S1. VTLM of D-CAR+ T cells and Aspergillus germling. D-CAR+ T cells (effector, E) were coincubated with GFP+ Aspergillus (AF293) swollen conidia (E:T ratio of 2:1), and one germling (target, T) was imaged continuously for 24 h by VTLM in phenol red-free culture medium. The movie shows the inhibition of growth of GFP+AF293 germinating conidia (green fluorescence) by D-CAR+ T cells.

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

Pappanaicken R. Kumaresan, Pallavi R. Manuri, Nathaniel D. Albert, Sourindra Maiti, Harjeet Singh, Tiejuan Mi, Jason Roszik, Brian Rabinovich, Simon Olivares, Janani Krishnamurthy, Ling Zhang, Amer M. Najjar, M. Helen Huls, Dean A. Lee, Richard E. Champlin, Dimitrios P. Kontoyiannis, and Laurence J. N. Cooper

PNAS. 2014. 111:10660-10665 DOI: 10.1073/pnas.1312789111