Video 1

Movie S1. Bilateral hind limb foot drop and hind leg weakness in an M83+/+ Tg mouse at 2 mo post IM injection of hfib21-140 αS. The foot drop progressed to paralysis and a moribund state within a week.

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Amanda N. Sacino, Mieu Brooks, Michael A. Thomas, Alex B. McKinney, Sooyeon Lee, Robert W. Regenhardt, Nicholas H. McGarvey, Jacob I. Ayers, Lucia Notterpek, David R. Borchelt, Todd E. Golde, and Benoit I. Giasson

PNAS. 2014. 111:10732-10737 DOI: 10.1073/pnas.1321785111