Video 1

Movie S1. Tubules emerge from maturing phagosomes several hours after phagocytosis in DCs. This movie shows the kinetics of tubule formation from phagosomes after pulsing WT BMDCs with LPS/OVA-TxR beads for 30 min and chasing for different times (0, 1 h, 2 h, or 6 h) as indicated. The time scale in seconds is indicated at the lower left.

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

Adriana R. Mantegazza, Allison L. Zajac, Alison Twelvetrees, Erika L. F. Holzbaur, Sebastián Amigorena, and Michael S. Marks

PNAS. 2014. DOI: 10.1073/pnas.1412998111