Video 1

Movie S1. Effect of AdoMet in the Bateman module of hCBS. The movie shows a side view of the Bateman module, and the relative rotation suffered by the CBS2 motif (in blue) with respect to the CBS1 motif (in yellow) upon AdoMet binding (not shown) to the site S2.

Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine

June Ereño-Orbea, Tomas Majtan, Iker Oyenarte, Jan P. Kraus, and Luis Alfonso Martínez-Cruz

PNAS. 2014. 111:E3845-E3852 DOI: 10.1073/pnas.1414545111