Video 1

Movie S1. WT worms on hmgs-1 RNAi. A movie of 30 frames per second showing day-1 adult WT worms grown from egg to adulthood on hmgs-1 RNAi. Treatment with hmgs-1 RNAi results in slow development, small body size, partial sterility, and severe worm paralysis.

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging

Amir Sapir, Assaf Tsur, Thijs Koorman, Kaitlin Ching, Prashant Mishra, Annabelle Bardenheier, Lisa Podolsky, Ulrike Bening-Abu-Shach, Mike Boxem, Tsui-Fen Chou, Limor Broday, and Paul W. Sternberg

PNAS. 2014. 111:E3880-E3889 DOI: 10.1073/pnas.1414748111