Video 1

Movie S1. Synchronized tubular necrosis. Dynamics of synchronized tubular necrosis upon depletion of fatty acids (see Materials and Methods for details). Note that the synchronized event occurs secondarily after initial necrosis of individual cells. The overall appearance after the synchronized necrotic event morphologically very much resembles casts in urine sediments of patients with acute tubular necrosis (ATN), the classical diagnosis of acute kidney injury (AKI).

Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann, Rachid Skouta, Nina Himmerkus, Shrikant R. Mulay, Christin Dewitz, Federica De Zen, Agnes Prokai, Gabriele Zuchtriegel, Fritz Krombach, Patrick-Simon Welz, Ricardo Weinlich, Tom Vanden Berghe, Peter Vandenabeele, Manolis Pasparakis, Markus Bleich, Joel M. Weinberg, Christoph A. Reichel, Jan Hinrich Bräsen, Ulrich Kunzendorf, Hans-Joachim Anders, Brent R. Stockwell, Douglas R. Green, and Stefan Krautwald

PNAS. 2014. DOI: 10.1073/pnas.1415518111