Movie S4. Erastin application induces synchronized tubular necrosis. In the presence of fatty acids, synchronized necrosis occurs within minutes [full movies range from 1 to 20 min (Movie S3) and 1–30 min (Movie S4 in higher resolution) after erastin addition to the perfusion solution]. Movies S3 and S4 represent two examples of this event in completely independent settings.
Andreas Linkermann, Rachid Skouta, Nina Himmerkus, Shrikant R. Mulay, Christin Dewitz, Federica De Zen, Agnes Prokai, Gabriele Zuchtriegel, Fritz Krombach, Patrick-Simon Welz, Ricardo Weinlich, Tom Vanden Berghe, Peter Vandenabeele, Manolis Pasparakis, Markus Bleich, Joel M. Weinberg, Christoph A. Reichel, Jan Hinrich Bräsen, Ulrich Kunzendorf, Hans-Joachim Anders, Brent R. Stockwell, Douglas R. Green, and Stefan Krautwald
PNAS. 2014. DOI: 10.1073/pnas.1415518111