Movie S1.

Ventricular epicardial optical mapping reveals complex patterns of AP wave propagation during spontaneous VF in RyR2-A4860G+/− heart under adrenergic stress and high extracellular Ca2+. Phase map movie shows 4 s of real-time activity (3,200 total frames acquired at 800 frames per second with a 30-ms delay set between each frame) during VF.

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

Yan-Ting Zhao, Carmen R. Valdivia, Georgina B. Gurrola, Patricia P. Powers, B. Cicero Willis, Richard L. Moss, José Jalife, and Héctor H. Valdivia

PNAS. 2015. 112:E1669-E1677 DOI: 10.1073/pnas.1419795112