Movie S2.

Extraction of PAPC substrate molecule from the membrane into the GVIA iPLA2 pocket using a steered MD simulation.

Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates

Varnavas D. Mouchlis, Denis Bucher, J. Andrew McCammon, and Edward A. Dennis