To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie S6. MD simulation of the GVIA iPLA2–PAPC complex showing the POPC molecules in the membrane patch near the enzyme binding pocket. Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates Varnavas D. Mouchlis, Denis Bucher, J. Andrew McCammon, and Edward A. Dennis PNAS. 2015. DOI: 10.1073/pnas.1424651112 Download Original Video Browse All Videos »