Movie S9.

The aligned structures during the MD simulations of GVIA iPLA2. (A) With PAPC in the binding pocket and in the presence of a POPC membrane patch (open state, cyan). (B) In the absence of a PAPC but in the presence of a POPC membrane patch (brown). (C) Starting in the open state and ending in aqueous solution in the absence of both PAPC and the POPC membrane patch (closed state, blue).