PI3K therapy accelerates focal adhesion turnover. LN229 cells expressing Talin-GFP to label focal adhesions were treated with vehicle or the indicated PI3K inhibitors for 48 h and analyzed by time-lapse fluorescence microscopy (60 s per frame). Magnification, 40×.
M. Cecilia Caino, Jagadish C. Ghosh, Young Chan Chae, Valentina Vaira, Dayana B. Rivadeneira, Alice Faversani, Paolo Rampini, Andrew V. Kossenkov, Katherine M. Aird, Rugang Zhang, Marie R. Webster, Ashani T. Weeraratna, Silvano Bosari, Lucia R. Languino, and Dario C. Altieri
PNAS. 2015. DOI: 10.1073/pnas.1500722112