Movie 2.

Platelet MPs are internalized by neutrophils in the presence of 12(S)-HETE. Shown are confocal microscopy and 3D reconstruction of activated neutrophils (red cytoplasm and blue nuclei) incubated with MPs (green) and 12(S)-HETE.

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

Anne-Claire Duchez, Luc H. Boudreau, James Bollinger, Clémence Belleannée, Nathalie Cloutier, Benoit Laffont, Raifish E. Mendoza-Villarroel, Tania Lévesque, Emmanuelle Rollet-Labelle, Matthieu Rousseau, Isabelle Allaeys, Jacques J. Tremblay, Patrice E. Poubelle, Gérard Lambeau, Marc Pouliot, Patrick Provost, Denis Soulet, Michael H. Gelb, and Eric Boilard

PNAS. 2015. 112:E3564-E3573 DOI: 10.1073/pnas.1507905112