To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie S1. Live engineered hPSC-CM. This cell was imaged by bright-field microscopy; its nucleus was labeled with Hoechst. The cell contracts along the pattern major axis. Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness Alexandre J. S. Ribeiro, Yen-Sin Ang, Ji-Dong Fu, Renee N. Rivas, Tamer M. A. Mohamed, Gadryn C. Higgs, Deepak Srivastava, and Beth L. Pruitt PNAS. 2015. 112:12705-12710 DOI: 10.1073/pnas.1508073112 Download Original Video Browse All Videos »