Movie S10.

Live engineered hPSC-CM imaged by fluorescence microscopy. Actin in myofibrils is labeled with Lifeact. The cell does not shorten when cultured on glass but contractile myofibril movement is evident.

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Alexandre J. S. Ribeiro, Yen-Sin Ang, Ji-Dong Fu, Renee N. Rivas, Tamer M. A. Mohamed, Gadryn C. Higgs, Deepak Srivastava, and Beth L. Pruitt

PNAS. 2015. 112:12705-12710 DOI: 10.1073/pnas.1508073112

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