Movie S10.

MIMIR can be conducted in old (23- to 25-mo-old) mice under physiological conditions. MIMIR of an old mouse shows active mitochondrial transport in axons (asterisks) with preserved blood flow (open arrow). Arrowheads indicate RGC cell bodies. Time is indicated as min:s.

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Yuji Takihara, Masaru Inatani, Kei Eto, Toshihiro Inoue, Alexander Kreymerman, Seiji Miyake, Shinji Ueno, Masatoshi Nagaya, Ayami Nakanishi, Keiichiro Iwao, Yoshihiro Takamura, Hirotaka Sakamoto, Keita Satoh, Mineo Kondo, Tatsuya Sakamoto, Jeffrey L. Goldberg, Junichi Nabekura, and Hidenobu Tanihara

PNAS. 2015. DOI: 10.1073/pnas.1509879112