Leak of small molecular dye Alexa Fluor 488 (green) from a capillary, visualized by Texas Red-dextran (red) in blood plasma without focal laser injury. After a short pulse of Alexa Fluor 488 (10 µL, administered through internal carotid artery) passes through the capillary, no diffusion of the dye to the surrounding tissue is visible outside the capillary. Scale (µm) and time (s) are indicated in the movie.