Movie S1.

Contractile response of PCLS derived from WT mice was determined following stimulation with a maximal (100 μM) concentration of the muscarinic agonist CCh. Shown is the live video feed of representative airways.

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction

Sophie J. Bradley, Coen H. Wiegman, Max Maza Iglesias, Kok Choi Kong, Adrian J. Butcher, Bianca Plouffe, Eugénie Goupil, Julie-Myrtille Bourgognon, Timothy Macedo-Hatch, Christian LeGouill, Kirsty Russell, Stéphane A. Laporte, Gabriele M. König, Evi Kostenis, Michel Bouvier, Kian Fan Chung, Yassine Amrani, and Andrew B. Tobin

PNAS. 2016. DOI: 10.1073/pnas.1521706113

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