Movie S4.

Neurovascular coupling at low frequencies (no time shift between neural and hemodynamics). Hemodynamics-corrected Thy1-GCaMP6f ΔF/F movie shown unfiltered (Left) and temporally low-pass filtered at 0.4 Hz (Middle) along with simultaneously acquired Δ[HbT] low-pass filtered at 0.4 Hz (corresponding to the peak of cross correlation between ΔF/F and Δ[HbT] across frequencies). This trial comes from an awake, resting-state mouse and corresponds to Fig. 3B and Movies S2 and S3. The 0.4-Hz LPF serves to temporally smooth the faster repetitive neural activity seen on the Left.

Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons

Ying Ma, Mohammed A. Shaik, Mariel G. Kozberg, Sharon H. Kim, Jacob P. Portes, Dmitriy Timerman, and Elizabeth M. C. Hillman

PNAS. 2016. DOI: 10.1073/pnas.1525369113