Evolution of KD distribution over SELEX cycles with an initial Gaussian distribution N(−4,0.4) for three values of the substrate concentration. This movie corresponds to Fig. 6 for all of the first 20 SELEX cycles.
Fabian Spill, Zohar B. Weinstein, Atena Irani Shemirani, Nga Ho, Darash Desai, and Muhammad H. Zaman
PNAS. 2016. 113:12076-12081 DOI: 10.1073/pnas.1605086113