Movie S1.

Variegation. Engineered domains were formed in clr4+ epe1∆ cells (top row) and clr4+ epe1+ cells (bottom row) by recruiting the Clr4 methyltransferase at the beginning of the video. At the first cell division, the methyltransferase was removed and the decay kinetics in the cells of both strains were followed. The average methylation level at the engineered locus is color-coded (white, unmethylated; red, methylated).