Movie S2.

Comparison of the transducer and the connectors during the recovery stroke. The SMM/CK-571 structure shows that the MD connectors are not coupled during the recovery stroke and allow the generation of the CK-571 pocket in an intermediate state that has features closer to the PR for the lever arm position and the connector positions but closer to the PPS for the transducer conformation.

Highly selective inhibition of myosin motors provides the basis of potential therapeutic application

Serena Sirigu, James J. Hartman, Vicente José Planelles-Herrero, Virginie Ropars, Sheila Clancy, Xi Wang, Grace Chuang, Xiangping Qian, Pu-Ping Lu, Edward Barrett, Karin Rudolph, Christopher Royer, Bradley P. Morgan, Enrico A. Stura, Fady I. Malik, and Anne M. Houdusse

PNAS. 2016. DOI: 10.1073/pnas.1609342113