Sequence differences between SMM and NMM are far from the CK-571 binding site (based on Fig. 2 and Fig. S1). Sequence differences between Hs-SMM2 and Hs-NMM2 are indicated with firebrick colored balls. Note that none of these differences are close to the path or the pocket that the drug will follow or occupy to act as an inhibitor.
Serena Sirigu, James J. Hartman, Vicente José Planelles-Herrero, Virginie Ropars, Sheila Clancy, Xi Wang, Grace Chuang, Xiangping Qian, Pu-Ping Lu, Edward Barrett, Karin Rudolph, Christopher Royer, Bradley P. Morgan, Enrico A. Stura, Fady I. Malik, and Anne M. Houdusse
PNAS. 2016. DOI: 10.1073/pnas.1609342113