Movie S1.

Top view of the shape changes that occur upon comparing the 4.7-Å resolution apo CMG to the 6.2 Å CMG–fork-DNA–ATP.

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation

Roxana Georgescu, Zuanning Yuan, Lin Bai, Ruda de Luna Almeida Santos, Jingchuan Sun, Dan Zhang, Olga Yurieva, Huilin Li, and Michael E. O’Donnell