Movie S6.

Time-lapse image of a centered, dual-labeled HIV particle challenging CHO-TRIMCypA cell in the presence of MG132 shows that the integrity of the capsid is maintained. (Left) Plotting of measured mean intensities with background subtracted (y axis) of the voxels from the tracked individual particle is shown at different time points in minutes (x axis). (Top Right) Particle box shows the signal of GFP (green) and Vpr (red) over time. (Bottom Right) Smaller boxes show the signal (gray) of each individual fluorescence measurement as labeled.

Early cytoplasmic uncoating is associated with infectivity of HIV-1

João I. Mamede, Gianguido C. Cianci, Meegan R. Anderson, and Thomas J. Hope

PNAS. 2017. 114:E7169-E7178 DOI: 10.1073/pnas.1706245114