To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie S2. A 15-ps QM/MM MD trajectory in which Asp407 is initially protonated. The water wire between protonated Asp407 and neutral His413 dissociates in agreement with classical simulation data (main text). Insights into functions of the H channel of cytochrome c oxidase from atomistic molecular dynamics simulations Vivek Sharma, Pablo G. Jambrina, Markus Kaukonen, Edina Rosta, and Peter R. Rich PNAS. 2017. 114:E10339-E10348 DOI: 10.1073/pnas.1708628114 Download Original Video Browse All Videos »