Movie S3.

Time-lapse video showing RICM and 4.7-pN tension imaging of human platelets engaged to a cRGD-decorated surface. Cell spreading and tension dynamics were captured from initial landing for a duration of 34 min. The third channel shows the tension data displayed using a colored heat map to better illustrate the relative intensity of the tension signal. (Scale bar: 10 μm.)

Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation

Yun Zhang, Yongzhi Qiu, Aaron T. Blanchard, Yuan Chang, Josh M. Brockman, Victor Pui-Yan Ma, Wilbur A. Lam, and Khalid Salaita

PNAS. 2017. 115:325-330 DOI: 10.1073/pnas.1710828115