Movie S2.

MD simulation of H206C dOrai. Multiple synchronized molecular renderings of a single simulation repeat (0 to 428 ns). Depictions of the channel are as described for Fig. S9. Na+ and Cl- ions are rendered as yellow and dark blue spheres respectively. Water molecules are shown as gray/red sticks within a cylinder centered along the central pore axis.

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Priscilla S.-W. Yeung, Megumi Yamashita, Christopher E. Ing, Régis Pomès, Douglas M. Freymann, and Murali Prakriya

PNAS. 2018. 115:E5193-E5202 DOI: 10.1073/pnas.1718373115