Movie S1.

Migration of WDR5 depleted cells in 3D collagen matrix. Representative movie of Control Jurkat (labeled with Red Cell-Tracer and Hoechst 33342) or WDR5.1 depleted (GFP+ and labeled with CFSE and Hoechst 33342) cells migrating in a 3D collagen gel (1.7 mg/ml). Cell movement was tracked and the movie shows the migration of cells in brightfield (S1) and fluorescence channels (S2) through the collagen matrix during 3 hours.