Ventricular systolic function is compromised with cardiac sarcomere disarray in the absence of CHD4. Chd4Δflox/Δflox embryo has slower, weaker ventricular contractions measured by blood flow velocity using PW Doppler echocardiography at the atrioventricularcanal.
Caralynn M. Wilczewski, Austin J. Hepperla, Takashi Shimbo, Lauren Wasson, Zachary L. Robbe, Ian J. Davis, Paul A. Wade, and Frank L. Conlon
PNAS. 2018. 115:6727-6732 DOI: 10.1073/pnas.1722219115