Three-dimensional reddening of peripherally engrafted CX3CR1+ monocytes engulfing β3-tubulin+ neuronal tissue 20 weeks after ocular injury. There dimensional rendering of confocal scans showing peripherally engrafted CX3CR1+ cells (semitransparent green) engulfing β3-tubulin+ cells (red) 20 weeks after acute ocular surface injury (right video panel). In contrast, CX3CR1+ microglia of naive eye do not engulf nor internalize β3-tubulin+ tissue, although they come in contact with β3-tubulin+ tissue (left video panel).
Eleftherios I. Paschalis, Fengyang Lei, Chengxin Zhou, Vassiliki Kapoulea, Reza Dana, James Chodosh, Demetrios G. Vavvas, and Claes H. Dohlman
PNAS. 2018. 115:E11359-E11368 DOI: 10.1073/pnas.1807123115