Movie S1.

Molecular modeling view. The movie represents the crystal structure of TIR1 (Gray), IAA (red), and the DII domain of IAA7 (green). The first sequence shows the best docking probability obtained for RN1 (yellow), RN2 (purple), RN3 (cyan), RN4 (orange) and RN4-8 (pink). The second sequence shows two chosen molecules for RN1 (yellow), RN3 (cyan) and RN4 (orange), corresponding to the best docking conformation, next to the conformation which thermodynamically stabilized TIR1 without the DIIdomain of IAA7.

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development

Thomas Vain, Sara Raggi, Noel Ferro, Deepak Kumar Barange, Martin Kieffer, Qian Ma, Siamsa M. Doyle, Mattias Thelander, Barbora Pařízková, Ondřej Novák, Alexandre Ismail, Per-Anders Enquist, Adeline Rigal, Małgorzata Łangowska, Sigurd Ramans Harborough, Yi Zhang, Karin Ljung, Judy Callis, Fredrik Almqvist, Stefan Kepinski, Mark Estelle, Laurens Pauwels, and Stéphanie Robert

PNAS. 2019. 116:6463-6472 DOI: 10.1073/pnas.1809037116