Movie S1.

Locomotor impairment of Parl-/- mouse. Two seven week-old Parl-/- mice show the typical locomotor impairment, severe muscle atrophy, and dyspnea, at difference with an age matched WT littermate.

PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome

Marco Spinazzi, Enrico Radaelli, Katrien Horré, Amaia M. Arranz, Natalia V. Gounko, Patrizia Agostinis, Teresa Mendes Maia, Francis Impens, Vanessa Alexandra Morais, Guillermo Lopez-Lluch, Lutgarde Serneels, Placido Navas, and Bart De Strooper

PNAS. 2018. 116:277-286 DOI: 10.1073/pnas.1811938116