Movie S1.

SBS-based modeling of the Shh locus from Wildtype cHiC maps 3D polymer model of wildtype limb cHi-C data. Note that the Shh gene (black) and the ZRS enhancer (green) are in close proximity and separated from the Mnx1 (purple) gene.

Preformed chromatin topology assists transcriptional robustness of Shh during limb development

Christina Paliou, Philine Guckelberger, Robert Schöpflin, Verena Heinrich, Andrea Esposito, Andrea M. Chiariello, Simona Bianco, Carlo Annunziatella, Johannes Helmuth, Stefan Haas, Ivana Jerković, Norbert Brieske, Lars Wittler, Bernd Timmermann, Mario Nicodemi, Martin Vingron, Stefan Mundlos, and Guillaume Andrey

PNAS. 2019. DOI: 10.1073/pnas.1900672116