Movie S1.

Molecular dynamics simulation of bithionol interacting with a 7DOPC:3DOPG lipid bilayer. Bithionol and sodium ions are depicted as large spheres, and phospholipids are represented as chains. The atoms in bithionol, phospholipids, and sodium ions are colored as follows: hydrogen, white; oxygen, red; nitrogen, blue; sulfur, yellow; chlorine, green; carbon, cyan; phosphorus, orange; sodium, blue. Water molecules are not shown for clarity. The outer blue lines indicate the periodic boundaries of the simulation boxes.

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

Wooseong Kim, Guijin Zou, Taylor P. A. Hari, Ingrid K. Wilt, Wenpeng Zhu, Nicolas Galle, Hammad A. Faizi, Gabriel L. Hendricks, Katerina Tori, Wen Pan, Xiaowen Huang, Andrew D. Steele, Erika E. Csatary, Madeline M. Dekarske, Jake L. Rosen, Noelly de Queiroz Ribeiro, Kiho Lee, Jenna Port, Beth Burgwyn Fuchs, Petia M. Vlahovska, William M. Wuest, Huajian Gao, Frederick M. Ausubel, and Eleftherios Mylonakis

PNAS. 2019. 116:16529-16534 DOI: 10.1073/pnas.1904700116