Movie S4.

LLPS of rIAPP. A drop of a 129 µM rIAPP-12.89 µM brIAPP-1.28 µM avidin fluoresceine reaction, in a 24.81 µl reaction volume, was pipetted in an uncoated glass bottom MatTek dish. The AWI (outer edge of the reaction drop) is on the left-hand side of the video. The arrowheads indicate droplets that will undergo fusion with one another.

Liquid–liquid phase separation of type II diabetes-associated IAPP initiates hydrogelation and aggregation

Lior Pytowski, Chiu Fan Lee, Alex C. Foley, David J. Vaux, and Létitia Jean

PNAS. 2020. 117:12050-12061 DOI: 10.1073/pnas.1916716117