Movie S2.

Random migration of ggps1- cells. Cells on the left were supplemented with 0.1 μM GGPP, cells on the right were supplemented with 0.2 μM GGPP. Video started 24 h after the addition of GGPP. Images were acquired every 10 min.

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Zhihua Jiao, Huaqing Cai, Yu Long, Orit Katarina Sirka, Veena Padmanaban, Andrew J. Ewald, and Peter N. Devreotes

PNAS. 2020. 117:4158-4168 DOI: 10.1073/pnas.1917938117