Movie S4.

Wild type and pten- cells stained with FM dye to visualize the initial steps of forming macropinosomes. FM dye was added from 30 s. Images were acquired every 10 s.

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Zhihua Jiao, Huaqing Cai, Yu Long, Orit Katarina Sirka, Veena Padmanaban, Andrew J. Ewald, and Peter N. Devreotes

PNAS. 2020. 117:4158-4168 DOI: 10.1073/pnas.1917938117