To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie S1. “pre-insertion OCCM” to “gate-closed OCCM” transition optimized with the finite-temperature string method with swarms of trajectories. Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6 Zuanning Yuan, Sarah Schneider, Thomas Dodd, Alberto Riera, Lin Bai, Chunli Yan, Indiana Magdalou, Ivaylo Ivanov, Bruce Stillman, Huilin Li, and Christian Speck PNAS. 2020. 117:17747-17756 DOI: 10.1073/pnas.2006231117 Download Original Video Browse All Videos »