Movie S2.

Global tilt and twist of ORC-Cdc6 with respect to Mcm2-7. Principal component 1 (PC1) captures the global tilt and twist of ORC-Cdc6.

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

Zuanning Yuan, Sarah Schneider, Thomas Dodd, Alberto Riera, Lin Bai, Chunli Yan, Indiana Magdalou, Ivaylo Ivanov, Bruce Stillman, Huilin Li, and Christian Speck

PNAS. 2020. 117:17747-17756 DOI: 10.1073/pnas.2006231117

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