To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie S3. Opening and closing of the Mcm2-Mcm5 gate. Principal component 2 (PC2) captures the opening of the loading gate to allow the passage of dsDNA and subsequent closing once dsDNA reaches the central channel of Mcm2-7 hexamer. Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6 Zuanning Yuan, Sarah Schneider, Thomas Dodd, Alberto Riera, Lin Bai, Chunli Yan, Indiana Magdalou, Ivaylo Ivanov, Bruce Stillman, Huilin Li, and Christian Speck PNAS. 2020. 117:17747-17756 DOI: 10.1073/pnas.2006231117 Download Original Video Browse All Videos »