Apilimod inhibits VSV-MeGFP-ZEBOV entry. Maximal Z-projection from four optical sections separated 0.25 μM apart of SVG-A cells gene-edited to express NPC1- Halo imaged by spinning disc confocal microscopy every 3 seconds for 3 min. Cells were infected with VSV-MeGFP-ZEBOV (MOI = 3) with or without 5 μM Apilimod and imaged ∼ 5 h post infection.
Yuan-Lin Kang, Yi-ying Chou, Paul W. Rothlauf, Zhuoming Liu, Timothy K. Soh, David Cureton, James Brett Case, Rita E. Chen, Michael S. Diamond, Sean P. J. Whelan, and Tom Kirchhausen
PNAS. 2020. DOI: 10.1073/pnas.2007837117