Movie S1.

WT (S1) and Il1a^-/- (S2) peritoneal macrophages were treated with LPS and ATP and stained with TMRM to observe mitochondrial membrane potential changes.

Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation

Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek-Iannucci, Yang Song, Shuang Chen, Malcolm Lane, Andrea Dorfleutner, Roberta A. Gottlieb, Christian Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, and Moshe Arditi

PNAS. 2020. 118:None-None DOI: 10.1073/pnas.2015632118

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