Movie S1.

HS-AFM of the IgG1-RGY – C1q complex in the presence of C1q in solution. HS-AFM movie of anti-DNP IgG1-RGY in complex with C1q (in the presence of C1q in solution). Initially detected C1q molecules subsequently dissociate from IgG hexamers. Image size: 400 × 400 nm² (100 × 100 pixel²), 1 s /frame.

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

Seline A. Zwarthoff, Kevin Widmer, Annemarie Kuipers, Jürgen Strasser, Maartje Ruyken, Piet C. Aerts, Carla J. C. de Haas, Deniz Ugurlar, Maurits A. den Boer, Gestur Vidarsson, Jos A. G. van Strijp, Piet Gros, Paul W. H. I. Parren, Kok P. M. van Kessel, Johannes Preiner, Frank J. Beurskens, Janine Schuurman, Daniel Ricklin, and Suzan H. M. Rooijakkers

PNAS. 2021. 118:None-None DOI: 10.1073/pnas.2102787118

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