Movie S2.

HS-AFM of the IgG1-RGY – C1 complex in the absence of C1 in solution. HS-AFM movie of anti-DNP IgG1-RGY in complex with C1 (in the absence of C1 in solution). C1 molecules remain stably bound to IgG hexamers during HS-AFM imaging. Image size: 400 × 400 nm² (100 × 100 pixel²), 1 s /frame.

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

Seline A. Zwarthoff, Kevin Widmer, Annemarie Kuipers, Jürgen Strasser, Maartje Ruyken, Piet C. Aerts, Carla J. C. de Haas, Deniz Ugurlar, Maurits A. den Boer, Gestur Vidarsson, Jos A. G. van Strijp, Piet Gros, Paul W. H. I. Parren, Kok P. M. van Kessel, Johannes Preiner, Frank J. Beurskens, Janine Schuurman, Daniel Ricklin, and Suzan H. M. Rooijakkers

PNAS. 2021. 118:None-None DOI: 10.1073/pnas.2102787118

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