Video 1
Movie S1. cAMP-induced conformational changes in the CNBD of human HCN2. Upon ligand binding (cAMP), the CNBD undergoes major rearrangements in the helical component (orange), including secondary structure formation (highlighted in red), whereas only minor movements are observed in the β-roll (blue).
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function
PNAS. 2014. 111:14577-14582 DOI: 10.1073/pnas.1410389111