Video 1

Movie S1. Spontaneous calcium bursts in vehicle-treated cortical neuron cultures. Fura-2 calcium imaging of vehicle-treated cortical neurons in ACSF after the addition of 5 μM GBZ, after the addition of GBZ plus 5 μM DNQX, and after neurons were depolarized with 55 mM KCl.

Topoisomerase 1 inhibition reversibly impairs synaptic function

Angela M. Mabb, Paul H. M. Kullmann, Margaret A. Twomey, Jayalakshmi Miriyala, Benjamin D. Philpot, and Mark J. Zylka

PNAS. 2014. 111:17290-17295 DOI: 10.1073/pnas.1413204111