Video 8

Movie S8. Dextran-ingesting myeloid cells display MMP activity but motile Gr-1 labeled neutrophils do not in an advanced PyMT/ACTB-ECFP tumor treated with control IgG for 3.5 wk, starting at 12 wk of age. MMPSense 680 probe (red) was injected intravenously 24 h before imaging, Alexa Fluor 594-labeled Gr-1 antibody (green) was injected intravenously 1 h before imaging, and FITC-labeled 10 kDa dextran (pink) was injected intravenously a few minutes after imaging was started. Tumor cells are seen in blue.

Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations

Marja Lohela, Amy-Jo Casbon, Aleksandra Olow, Lynn Bonham, Daniel Branstetter, Ning Weng, Jeffrey Smith, and Zena Werb

PNAS. 2014. 111:E5086-E5095 DOI: 10.1073/pnas.1419899111