Movie S1.

Rotation of the plot in Fig. 6A, showing the planar relation between the protein construct’s in-cell motions (mobilityin cell; Eq. 3) and their surface properties, i.e., the surface net charge density (chargedensity; Eq. 5) and the surface hydrophilicity (hydrophilicityGuy; Eq. 7). The wild-type proteins are represented by ■ (black solid squares), the pseudo-wild-type variants by • (black solid circles), and the mutants by ❍ (colored solid circles), color-coded according to Fig. 1.