Movie S7.

Breast cancer cells disseminated in the BoPV niche-on-chip exposed to interstitial flow. Video showing a live 3D confocal reconstruction of breast cancer cells (green; GFP-transduced MDA-MB-231) within the perivascular niches containing MSCs and RFP-expressing ECs (red) cultured under interstitial flow.

Human bone perivascular niche-on-a-chip for studying metastatic colonization

Alessandro Marturano-Kruik, Michele Maria Nava, Keith Yeager, Alan Chramiec, Luke Hao, Samuel Robinson, Edward Guo, Manuela Teresa Raimondi, and Gordana Vunjak-Novakovic

PNAS. 2018. 115:1256-1261 DOI: 10.1073/pnas.1714282115